Worked for a bit then just won't load

I have the first Syberia game and it worked two times, then when I clicked on the icon to play it once again it won't load. I get a popup that says "Do you want to allow the following program from an unknown publisher to make changes to this computer"

Program name: Syberia.exe
Publisher: Unknown
File Origin: Hard Drive on this computer
Program Location: C:/Program Files (x86)/Microids/Syberia/Syberia.exe

and then nothing happens when I click yes :(

Worked for a bit then just won't load